Sensitive neurocognitive markers of neurodegeneration: A multi-feature framework

We will establish the sensitivity of novel social cognition and embodied task and related neurocognitive markers with a multi-feature framework allowing comparisons with classical cognitive and neuroimaging assessments (i.e., structural MRI, functional connectivity derived from fMRI) for characterizing NDs subtypes (AD, FTD, PD), and predicting disease progression. We will test the main hypothesis that multimodal neurocognitive markers will prove more powerful than classical cognitive and standard neuroimaging markers to characterize disease subtypes and disease severity, irrespective of the patients’ socioeconomic status