Mainstream

Primary Progressive Aphasia (PPA) is a syndrome due to different neurodegenerative disorder selectively disrupting language functions. Recently attention has been gained by new techniques that allow for non-invasive brain stimulation such as transcranial direct current stimulation (tDCS). PPA specialist care is underdeveloped. There are very few specialists (neurologists, psychiatrists, neuropsychologists and speech therapists) and few hospital- or community- based services dedicated to diagnosis and continuing care. Currently, healthcare systems struggle to provide adequate coverage of diagnostic services, and care is too often fragmented, uncoordinated, and unresponsive to the needs of people living with PPA patients and their families. Our goal is to develop a new diagnostic and treatment approach in PPA in which the regional secondary care centers participating in this project will act asshould be the hub of a regional nework system. We have divided the healthcare provided for to people living with PPA into four phases: 1. Detection and diagnosis (WP1); 2. Early post-diagnostic care (WP2); 3. Continuing care with telerehabilitation (WP3); 4. a clinical trialFinally, in a subgroup of very mild PPA we will also conduct a clinical trial (WP4). This approach will allow us to develop a tailored ad-hocprecision medicine diagnosis and treatment system for people living with PPA, in including in-hospital and setting and in at home settings.